Afficher la couverture 'Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant | van den Eeckhout, Bram' en grand format
/5

0 avis

Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant

Archive ouverte

van den Eeckhout, Bram | van Hoecke, Lien | Burg, Elianne | van Lint, Sandra | Peelman, Frank | Kley, Niko | Uzé, Gilles | Saelens, Xavier | Tavernier, Jan | Gerlo, Sarah

Edité par CCSD ; Nature Research -

International audience. Annual administration and reformulation of influenza vaccines is required for protection against seasonal infections. However, the induction of strong and long-lasting T cells is critical to reach broad and potentially lifelong antiviral immunity. The NLRP3 inflammasome and its product interleukin-1β (IL-1β) are pivotal mediators of cellular immune responses to influenza, yet, overactivation of these systems leads to side effects, which hamper clinical applications. Here, we present a bypass around these toxicities by targeting the activity of IL-1β to CD8 + T cells. Using this approach, we demonstrate safe inclusion of IL-1β as an adjuvant in vaccination strategies, leading to full protection of mice against a high influenza virus challenge dose by raising potent T cell responses. In conclusion, this paper proposes a class of IL-1β-based vaccine adjuvants and also provides further insight in the mechanics of cellular immune responses driven by IL-1β. npj Vaccines (2020) 5:64 ; https://doi.

Suggestions

Du même auteur

Selective IL-1 activity on CD8+ T cells empowers antitumor immunity and synergizes with neovasculature-targeted TNF for full tumor eradication

Archive ouverte | van den Eeckhout, Bram | CCSD

International audience. Background: Clinical success of therapeutic cancer vaccines depends on the ability to mount strong and durable antitumor T cell responses. To achieve this, potent cellular adjuvants are highl...

Targeting IFN activity to both B cells and plasmacytoid dendritic cells induces a robust tolerogenic response and protection against EAE

Archive ouverte | Cauwels, Anje | CCSD

International audience

A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state

Archive ouverte | van Lint, Sandra | CCSD

International audience. Despite major improvements in immunotherapeutic strategies, the immunosuppressive tumor microenvironment remains a major obstacle for the induction of efficient antitumor responses. In this s...

Chargement des enrichissements...