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The nucleocytoplasmic rabies virus P protein counteracts interferon signaling by inhibiting both nuclear accumulation and DNA binding of STAT1.

Archive ouverte | Vidy, Aurore | CCSD

International audience. Rabies virus P protein inhibits alpha interferon (IFN-alpha)- and IFN-gamma-stimulated Jak-STAT signaling by retaining phosphorylated STAT1 in the cytoplasm. Here, we show that P also blocks ...

Implication of PMLIV in Both Intrinsic and Innate Immunity

Archive ouverte | El Asmi, Faten | CCSD

International audience. PML/TRIM19, the organizer of nuclear bodies (NBs), has been implicated in the antiviral response to diverse RNA and DNA viruses. Several PML isoforms generated from a single PML gene by alter...

Dual modes of rabies P-protein association with microtubules : a novel strategy to suppress the antiviral response

Archive ouverte | Moseley, Gregory M. | CCSD

International audience. Conventional nuclear import is independent of the cytoskeleton, but recent data have shown that the import of specific proteins can be either facilitated or inhibited by microtubules (MTs). N...

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