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Targeted gene therapy of Xeroderma pigmentosum cells using meganuclease and TALEN™

Archive ouverte | Dupuy, Aurélie | CCSD

Xeroderma pigmentosum group C (XP-C) is a rare human syndrome characterized by hypersensitivity to UV light and a dramatic predisposition to skin neoplasms. XP-C cells are deficient in the nucleotide excision repair (NER) pathway,...

Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing

Archive ouverte | Jo, Sumin | CCSD

International audience. Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to...

Efficient in toto targeted recombination in mouse liver by meganuclease‐induced double‐strand break

Archive ouverte | Gouble, Agnès | CCSD

International audience. Background Sequence‐specific endonucleases with large recognition sites can cleave DNA in living cells, and, as a consequence, stimulate homologous recombination (HR) up to 10 000‐fold. The r...

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