Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan

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Yagi, Sakina | Mohammed, Atif | Tzanova, Tzvetomira | Schohn, Hervé | Abdelgadir, Haider | Stefanucci, Azzurra | Mollica, Adriano | Zengin, Gokhan

Edité par CCSD ; Wiley -

International audience. Essential oils from the inflorescence of Cymbopogon schoenanthus and C. nervatus growing in Northern Sudan were examined for their chemical composition, antiproliferative activity against human breast carcinoma and human colon adenocarcinoma cell lines, antioxidant activity (phosphomolybdenum, antiradical, reducing power, and ferrous chelating), and enzyme inhibition activity against acetylcholinesterase butyrylcholinesterase, tyrosinase, α‐glucosidase, and α‐amylase. In silico study on the inhibition of tyrosinase and α‐amylase was also performed. Piperitone (59.1%) and isomers of para‐menthadienols (35.3%) were the main compounds in C. schoenanthus and C. nervatus oils, respectively. Oil from C. nervatus possessed higher antioxidant activity than that from C. schoenanthus except for its metal chelating ability. Both oils showed high antiproliferative activity. In silico study showed that trans‐p‐mentha‐2,8‐dien‐1‐ol and piperitone (both isomers) revealed the best docking scores for α‐amylase and tyrosinase, respectively. In conclusion, oils from these two Cymbopogon species could be new natural agents with functional properties for food, cosmetics, and pharmaceutical industries.

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