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Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma.

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Jülhing, Frank | Hamdane, Nourdine | Crouchet, Emilie | Li, Shen | El Saghire, Houssein | Mukherji, Atish | Fujiwara, Naoto | Oudot, Marine A. | Thumann, Christine | Saviano, Antonio | Roca Suarez, Armando Andres | Goto, Kaku | Masia, Ricard | Sojoodi, Mozhdeh | Arora, Gunisha | Aikata, Hiroshi | Ono, Atsushi | Tabrizian, Parissa | Schwartz, Myron | Polyak, Stephen J | Davidson, Irwin | Schmidl, Christian | Bock, Christoph | Schuster, Catherine | Chayama, Kazuaki | Pessaux, Patrick | Tanabe, Kenneth K | Hoshida, Yujin | Zeisel, Mirjam | Duong, Francois Ht | Fuchs, Bryan C | Baumert, Thomas

Edité par CCSD ; BMJ Publishing Group -

Hepatocellular carcinoma (HCC) is the fastest-growing cause of cancer-related mortality with chronic viral hepatitis and non-alcoholic steatohepatitis (NASH) as major aetiologies. Treatment options for HCC are unsatisfactory and chemopreventive approaches are absent. Chronic hepatitis C (CHC) results in epigenetic alterations driving HCC risk and persisting following cure. Here, we aimed to investigate epigenetic modifications as targets for liver cancer chemoprevention.

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