Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET)

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Vasseur, Antoine | Cabel, Luc | Trédan, Olivier | Chevrier, Marion | Dubot, Coraline | Lorgis, Veronique | Jacot, William | Gonçalves, Anthony | Debled, Marc | Lévy, Christelle | Ferrero, Jean-Marc | Jouannaud, Christelle, G | Luporsi, Elisabeth | Mouret-Reynier, Marie-Ange | Dalenc, Florence | Lemonnier, Jérôme | Savignoni, Alexia | Tanguy, Marie-Laure | Bidard, François-Clément | Pierga, Jean-Yves

Edité par CCSD ; Springer Verlag -

International audience. Proof of concept studies has reported that circulating endothelial cell (CEC) count may be associated with the outcome of HER2-negative metastatic breast cancer (mBC) patients treated by chemotherapy and the anti-VEGF antibody bevacizumab. We report the results obtained in an independent prospective validation cohort (COMET study, NCT01745757).

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