Bevacizumab and platinum-based combinations for recurrent ovarian cancer: a randomised, open-label, phase 3 trial
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Pfisterer, Jacobus | Shannon, Catherine | Baumann, Klaus | Rau, Joern | Harter, Philipp | Joly, Florence | Sehouli, Jalid | Canzler, Ulrich | Schmalfeldt, Barbara | Dean, Andrew | Hein, Alexander | Zeimet, Alain | Hanker, Lars | Petit, Thierry | Marme, Frederik | El-Balat, Ahmed | Glasspool, Rosalind | de Gregorio, Nikolaus | Mahner, Sven | Meniawy, Tarek | Park-Simon, Tjoung-Won | Mouret-Reynier, Marie-Ange | Costan, Cristina | Meier, Werner | Reinthaller, Alexander | Goh, Jeffrey | L'Haridon, Tifenn | Baron Hay, Sally | Kommoss, Stefan | Du Bois, Andreas | Kurtz, Jean-Emmanuel | Ackermann, Sven | Anthuber, Christoph | Aydogdu, Mustafa | Baldauf, Angelika | Bauer, Wolfgang | Behringer, Dirk | Belau, Antje | Bender, Alexandra | Brucker, Cosima | Burges, Alexander | Daabach, Trygve | Denschlag, Dominik | Deryal, Mustafa | Dörfel, Steffen | Ebert, Juliane | Fehm, Tanja | Feidicker, Susanne Maria | Feisel-Schwickardi, Gabriele | Felberbaum, Ricardo | Frank, Matthias | Gebauer, Gerhard | Gerber, Bernd | Gerhardt, Axel | Grafe, Andrea | Griesshammer, Martin | Grischke, Eva-Maria | Gröll, Isolde | Gropp-Meier, Martina | Hager, Dietrich | Hanf, Volker | Hannig, Carla Verena | Hantschmann, Peer | Hauzenberger, Tanja | Herwig, Uwe | Heubner, Martin | Hielscher, Carsten | Hilpert, Felix | Hitschold, Thomas | Hofmann, Manfred | Jackisch, Christian | Janni, Wolfgang | Kiesel, Ludwig | Ko, Yon-Dschun | Koch, Hans-Joachim | Krabisch, Petra | Krieger, Peter | Kubin, Thomas | Kühn, Thorsten | Lampe, Björn | Ledwon, Peter | Lemster, Sabine | Lex, Benno | Liebrich, Clemens | Lorenz, Ralf | Lück, Hans-Joachim | Mallmann, Peter | Meinerz, Wolfgang | Menke, Götz | Möbus, Volker | Muller, Thomas | Müller, Volker | Neunhöffer, Tanja | Ober, Angelika | Oskay-Özcelik, Gülten | Ostertag, Horst | Pölcher, Martin | Rautenberg, Beate | Rein, Daniel | Reiter, Wilhelm | Rempen, Andreas | Runnebaum, Ingo | Schmidt, Marcus | Schnohr, Sabine | Scholz, Heinz | Schröder, Willibald | Simon, Eike | Sperfeld, Antje | Steckkönig, Annette | Strauss, Hans-Georg | Stuth, Ronaldo | Terhaag, Jürgen | Thiel, Falk | Thill, Marc | Tomé, Oliver | Uleer, Christoph | Vogel, Susanne | Voss, Hermann | Weigel, Michael | Winkler, Ulrich | Wischnik, Arthur | Zeiser, Tobias | Zorr, Andreas | Glasspool, Ros | Hudson, Emma | Jones, Rachel | Lafleur, Judith | Marth, Christian | Petru, Edgar | Antill, Yoland | Azer, Mary | Baron-Hay, Sally | Beale, Philip | Begbie, Stephen | Black, Allison | Briscoe, Karen | Harvey, Sandra | Lee, Chee | Matos, Marco | Olesen, Inger | Vasey, Paul | Abadie-Lacourtoisie, Sophie | Arsene, Olivier | Barthier, Sophie | Becuwe-Roemer, Célia | Berton-Rigaud, Dominique | Cappiello-Bataller, Maria | Catala, Stéphanie | del Piano, Francesco | Deplanque, Gaël | Despax, Raymond | Dohollou, Nadine | Garnier-Tixidré, Claire | Grenier, Julien | Guardiola, Emmanuel | Hardy-Bessard, Anne-Claire | Lefeuvre-Plesse, Claudia | Leheurteur, Marianne | Lesoin, Anne | Levache, Charles-Briac | Longo, Raffaele | Lortholary, Alain | Meunier, Jérôme | Raban, Nadia | Romano, Olivier | Vannetzel, Jean-Michel | Zannetti, Alain
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CCSD ; Elsevier -
International audience.
State-of-the art therapy for recurrent ovarian cancer suitable for platinum-based re-treatment includes bevacizumab-containing combinations (eg, bevacizumab combined with carboplatin-paclitaxel or carboplatin-gemcitabine) or the most active non-bevacizumab regimen: carboplatin-pegylated liposomal doxorubicin. The aim of this head-to-head trial was to compare a standard bevacizumab-containing regimen versus carboplatin-pegylated liposomal doxorubicin combined with bevacizumab.
