Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers

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Croissant, Jonas | Maynadier, Marie | Gallud, Audrey | Peindy n'Dongo, Harmel | Nyalosaso, Jeff | Derrien, Gaëlle | Charnay, Clarence | Durand, Jean-Olivier | Raehm, Laurence | Serein-Spirau, Françoise | Cheminet, Nathalie | Jarrosson, Thibaut | Mongin, Olivier | Blanchard-Desce, Mireille | Gary-Bobo, Magali | Garcia, Marcel | Lu, Jie | Tamanoi, Fuyuhiko | Tarn, Derrick | Guardado-Alvarez, Tania | Zink, Jeffrey, I.

Edité par CCSD ; Wiley-VCH Verlag -

International audience. A therapy of cancer cells: Two-photon-triggered camptothecin delivery (see picture) with nanoimpellers was studied in MCF-7 breast cancer cells. A fluorophore with a high two-photon absorption cross-section was first incorporated in the nanoimpellers. Fluorescence resonance energy transfer (FRET) from the fluorophore to the azobenzene moiety was demonstrated.

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