RNA sequencing analysis of activated macrophages treated with the anti-HIV ABX464 in intestinal inflammation

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Manchon, Laurent | Chébli, Karim | Papon, Laura | Paul, Conception | Garcel, Aude | Campos, Noëlie | Scherrer, Didier | Ehrlich, Hartmut | Hahne, Michael | Tazi, Jamal

Edité par CCSD ; Nature Publishing Group -

International audience. RNA-Seq enables the generation of extensive transcriptome information providing the capability to characterize transcripts (including alternative isoforms and polymorphism), to quantify expression and to identify differential regulation in a single experiment. To reveal the capacity of new anti-HIV ABX464 candidate in modulating the expression of genes, datasets were generated and validated using RNA-seq approach. This comprehensive dataset will be useful to deepen the comprehensive understanding of the progression of human immunodeficiency virus (HIV) associated with mucosal damage in the gastrointestinal (GI) tract and subsequent inflammation, providing an opportunity to generate new therapies, diagnoses, and preventive strategies.

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