Syracuse

Peptides increasing the secretion and/or expression of at least one gastrointestinal mucin and/or inducing an increase in the population of mucus cells or paneth cells. Peptides augmentant la secrétion et/ou l'expression d'au moins une mucine gastrointestinale et/ou induisant l'augmentation de la population de cellules à mucus ou de cellules de paneth.

Archive ouverte

Plaisancié, Pascale | Claustre, Jean | Estienne, Monique | Jourdan, Gérard | Léonil, Joelle | Henry, Gwenaele | Mollé, Daniel | Madec, Marie-Noelle | Boutrou, Rachel | Paquet, Armelle

Edité par CCSD -

Date de publication et mention de la délivrance du brevet: 06.03.2019 Bulletin 2019/10. The invention relates to a polypeptide including or consisting of SEQ ID NO: 1, or a sequence at least 80% identical to SEQ ID NO: 1, or a sequence of at least 4 consecutive amino acids included in SEQ ID NO: 1, wherein said polypeptide has at least one effect selected from: inducing the expression and/or the secretion of at least one gastrointestinal mucin; and inducing the expression and/or the secretion of at least one intestinal defense molecule expressed by Paneth cells; and inducing an increase in the population of mucus cells and/or in the population of Paneth cells, with the proviso that the polypeptide does not include the SEQ ID NO: 2 sequence.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion