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TLR4-and TLR2-mediated B cell responses control the clearance of the bacterial pathogen Leptospira interrogans

Archive ouverte | Chassin, Cécilia | CCSD

International audience. Leptospirosis is a widespread zoonosis caused by pathogenic Leptospira interrogans that are transmitted by asymptomatic infected rodents. Leptospiral lipoproteins and LPS have been shown to s...

Leptospira Interrogans Induces Fibrosis in the Mouse Kidney through Inos-Dependent, TLR- and NLR-Independent Signaling Pathways

Archive ouverte | Fanton d'Andon, Martine | CCSD

International audience. Leptospira (L.) interrogans are bacteria responsible for a worldwide reemerging zoonosis. Rodents carry L. interrogans asymptomatically in their kidneys and excrete bacteria in the urine, con...

Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions

Archive ouverte | Vandewalle, Alain | CCSD

International audience. The calcineurin/nuclear factor of activated T cells (NFATs) signaling pathway plays a central role in T cell mediated adaptive immune responses, but a number of recent studies demonstrated th...

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