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Assisted Reproductive Technology affects developmental kinetics, H19 Imprinting Control Region methylation and H19 gene expression in individual mouse embryos

Archive ouverte | Fauque, Patricia | CCSD

International audience. Background: In the last few years, an increase in imprinting anomalies has been reported in children born from Assisted Reproductive Technology (ART). Various clinical and experimental studie...

In Vitro Fertilization and Embryo Culture Strongly Impact the Placental Transcriptome in the Mouse Model

Archive ouverte | Fauque, Patricia | CCSD

International audience. BACKGROUND: Assisted Reproductive Technologies (ART) are increasingly used in humans; however, their impact is now questioned. At blastocyst stage, the trophectoderm is directly in contact wi...

Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men

Archive ouverte | Chalas Boissonnas, Céline | CCSD

International audience. DNA methylation marks, a key modification of imprinting, are erased in primordial germ cells and sex specifically re-established during gametogenesis. Abnormal epigenetic programming has been...

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