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The Physical Relationship between Infectivity and Prion Protein Aggregates Is Strain-Dependent

Archive ouverte | Tixador, Philippe | CCSD

International audience. Prions are unconventional infectious agents thought to be primarily composed of PrPSc, a multimeric misfolded conformer of the ubiquitously expressed host-encoded prion protein (PrPC). They c...

Prnp knockdown in transgenic mice using RNA interference

Archive ouverte | Gallozzi, Micaela | CCSD

International audience. RNA interference has become a widely used approach to perform gene knockdown experiments in cell cultures and more recently transgenic animals. A designed miRNA targeting the prion protein mR...

Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics

Archive ouverte | Laferrière, Florent | CCSD

International audience. Prions are proteinaceous infectious agents responsible for fatal neurodegenerative diseases in animals and humans. They are essentially composed of PrPSc, an aggregated, misfolded conformer o...

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