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Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes

Archive ouverte | Madore, Charlotte | CCSD

International audience. Low dietary intake of the n-3 polyunsaturated fatty acids (PUFAs) is a causative factor of neurodevelopmental disorders. However the mechanisms linking n-3 PUFAs low dietary intake and neurod...

N-3 polyunsaturated fatty acids protect against the cognitive effects of a peripheral inflammation by targeting microglia morphofunctional activity

Archive ouverte | Delpech, Jean-Christophe | CCSD

International audience. Microglia is the main cellular component of the cerebral innate immune system. During a peripheral immune challenge, microglial cells are activated, leading to alteration of hippocampal memor...

Dietary n-3 PUFAs deficiency increases vulnerability to inflammation-induced spatial memory impairment

Archive ouverte | Delpech, Jean-Christophe | CCSD

International audience. Dietary n-3 polyunsaturated fatty acids (PUFAs) are critical components of inflammatory response and memory impairment. However, the mechanisms underlying the sensitizing effects of low n-3 P...

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