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Analysis of glycosylphosphatidylinositols of a virulent and a non virulent strain of Toxoplasma gondii. Possible role in parasite virulence

Archive ouverte | Niehus, Sebastian | CCSD

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Virulent and avirulent strains of Toxoplasma gondii which differ in their glycosylphosphatidylinositol content induce similar biological functions in macrophages

Archive ouverte | Niehus, Sebastian | CCSD

Glycosylphosphatidylinositols (GPIs) from several protozoan parasites are thought to elicit a detrimental stimulation of the host innate immune system aside their main function to anchor surface proteins. Here we analyzed the GPI ...

Toxoplasma gondii grown in human cells uses GalNAc-containing glycosylphosphatidylinositol precursors to anchor surface antigens while the immunogenic Glc-GalNAc-containing precursors remain free at the parasite cell surface.

Archive ouverte | Azzouz, Nahid | CCSD

Toxoplasma gondii is a ubiquitous parasite that infects nearly all warm-blooded animals. Developmental switching in T. gondii, from the virulent tachyzoite to the relatively quiescent bradyzoite stage, is responsible for the disea...

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