Suggestions

Du même auteur

Selective activation of estrogen receptor alpha activation function-1 is sufficient to prevent obesity, steatosis, and insulin resistance in mouse

Archive ouverte | Guillaume, Maeva | CCSD

Estrogen receptor alpha (ER alpha) regulates gene transcription through two activation functions (ER alpha-AF1 and ER alpha-AF2). We recently found that the protection conferred by 17 beta-estradiol against obesity and insulin res...

Selective Liver Estrogen Receptor Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice

Archive ouverte | Guillaume, Maeva | CCSD

International audience. Hepatocyte estrogen receptor α (ERα) was recently recognized as a relevant molecular target for nonalcoholic fatty liver disease (NAFLD) prevention. The present study defined to what extent h...

Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target

Archive ouverte | Smati, Sarra | CCSD

International audience. Objective We evaluated the influence of sex on the pathophysiology of non-alcoholic fatty liver disease (NAFLD). We investigated diet-induced phenotypic responses to define sex-specific regul...

Chargement des enrichissements...