Subretinal drusenoid deposits in an elderly population with age-related macular degeneration (MONTRACHET study: Maculopathy, Optic Nerve, nuTRition, neurovasCular and HEarT diseases)

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Gabrielle, Pierre-Henry | de Lazzer, Aurélie | Koehrer, Philippe | Devilliers, Hervé | Arnoult, Louis | Daniel, Sandrine | Binquet, Christine | Tzourio, Christophe | Bron, Alain Marie | Creuzot, Catherine

Edité par CCSD ; John Wiley and Sons -

National audience. Purpose To determine the frequency of subretinal drusenoid deposits (SDD) in a French population of elderly patients presenting an age‐related macular degeneration (AMD) in the MONTRACHET study. Methods The three‐city study (3C) was a population‐based study including 9294 patients older than 65 years from three French cities (Dijon, Bordeaux and Montpellier) at baseline in 1999. After 10 years, the cohort of Dijon benefited from a complete ophthalmologic examination as part of the MONTRACHET study. Each patient underwent a non‐mydriatic retinophotography associated with a spectral‐domain OCT examination (SD‐OCT) of the macula. AMD classification was established according to the classification of the Multi‐Ethnic study of Atherosclerosis (MESA) for the retinophotography analysis and with the E3 CONSORTIUM classification for the SD‐OCT analysis. Patients with uninterpretable images of both eyes were excluded from statistical analysis. Results One thousand one hundred fifty three subjects were included. 62.7% were female and the mean age was 82.2 ± 3.8 years. With retinophotography analysis, the frequency of SDD was 1.9% (n = 38 eyes). With the SD‐OCT macular analysis, the frequency of SDD was 14.8% (n = 342). In patients presenting with SDD, 68.8% (n = 137) had a bilateral involvement. The relative risk (RR) of presenting SDD lesions in patients older than 80 years old was 2.6 (p < 0.001) and in women at 1.3 (p < 0.045). An interruption of the ellipsoide line and an alteration of the retinal pigment epithelium were statistically associated with the presence of SDD: RR = 5.9 (p < 0.001) and RR = 2.8 (p < 0.001), respectively. The average thickness of the subfoveal choroid was thinner in subjects presenting SDD (174.9 μm with SDD vs 209.8 μm without SDD, p < 0.001). Conclusions Few population‐based studies have established the frequency of SDD in an elderly population.

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