Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

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Béringue, Vincent | Herzog, Laetitia | Reine, Fabienne | Le Dur, Annick | Casalone, Cristina | Vilotte, Jean-Luc | Laude, Hubert, H.

Edité par CCSD ; Centers for Disease Control and Prevention -

International audience. To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met with fi eld isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.

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