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TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

Archive ouverte | Ye, Jing | CCSD

Human telomeres are protected from DNA damage by a nucleoprotein complex that includes the repeat-binding factor TRF2. Here, we report that TRF2 regulates the 5′ exonuclease activity of its binding partner, Apollo, a member of the...

TRF2 promotes, remodels and protects telomeric Holliday junctions.

Archive ouverte | Poulet, Anaïs | CCSD

International audience. The ability of the telomeric DNA-binding protein, TRF2, to stimulate t-loop formation while preventing t-loop deletion is believed to be crucial to maintain telomere integrity in mammals. How...

The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair

Archive ouverte | Lenain, Christelle | CCSD

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