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TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

Archive ouverte | Ye, Jing | CCSD

Human telomeres are protected from DNA damage by a nucleoprotein complex that includes the repeat-binding factor TRF2. Here, we report that TRF2 regulates the 5′ exonuclease activity of its binding partner, Apollo, a member of the...

A topological mechanism for TRF2-enhanced strand invasion

Archive ouverte | Amiard, Simon | CCSD

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Targeting assay to study the cis functions of human telomeric proteins: Evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2

Archive ouverte | Ancelin, Katia | CCSD

International audience

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