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TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

Archive ouverte | Biroccio, Annamaria | CCSD

International audience. Dysfunctional telomeres suppress tumour progression by activating cell-intrinsic programs that lead to growth arrest. Increased levels of TRF2, a key factor in telomere protection, are observ...

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment

Archive ouverte | Zizza, Pasquale | CCSD

International audience. The telomeric protein TRF2 is overexpressed in several human malignancies and contributes to tumori-genesis even though the molecular mechanism is not completely understood. By using a high-t...

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

Archive ouverte | Ye, Jing | CCSD

Human telomeres are protected from DNA damage by a nucleoprotein complex that includes the repeat-binding factor TRF2. Here, we report that TRF2 regulates the 5′ exonuclease activity of its binding partner, Apollo, a member of the...

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