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Single-Nucleotide Polymorphism-Defined Class I and Class III Major Histocompatibility Complex Genetic Subregions Contribute to Natural Long-term Nonprogression in HIV Infection

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Guergnon, J. | Dalmasso, C. | Broet, P. | Meyer, L. | Westrop, S. J. | Imami, N. | Vicenzi, E. | Morsica, G. | Tinelli, M. | Poma, B. Zanone | Goujard, C. | Potard, V. | Gotch, F. M. | Casoli, C. | Cossarizza, A. | Macciardi, F. | Debré, P. | Delfraissy, J. F. | Galli, M. | Autran, B. | Costagliola, D. | Poli, G. | Theodorou, I. | Riva, A. | Consortium, G. I. S. H. E. A. L.

Edité par CCSD ; Oxford University Press -

International audience. We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate, <0.05) with the LTNP condition, among which 5 reached genome-wide significance after Bonferonni correction. The MHC LTNP-associated SNPs are ordered in >= 4 linkage disequilibrium blocks; interestingly, an MHC class III linkage disequilibrium block (defined by the rs9368699 SNP) seems specific to the LTNP phenotype.

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