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MRE11–RAD50–NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair

Archive ouverte | Roques, Céline | CCSD

International audience. Monoubiquitination of the Fanconi anaemia protein FANCD2 is a key event leading to repair of interstrand cross-links. It was reported earlier that FANCD2 co-localizes with NBS1. However, the ...

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses.

Archive ouverte | Turaga, Ramachander V. N. | CCSD

International audience. Werner syndrome (WS) is characterized by the premature onset of several age-associated pathologies. The protein deficient in WS (WRN) is a RecQ-type DNA helicase involved in DNA repair, repli...

A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2

Archive ouverte | d'Andrea, Alan, D. | CCSD

Emilie L Dubois : CHU de Québec Research Center, HDQ Pavilion, Oncology Division, 9 McMahon, Québec City, QC G1R 3S3, Canada - Department of Molecular Biology, Medical Biochemistry and Pathology; Laval University Cancer Research C...

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