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Molecular markers and in vitro susceptibility to doxycycline in plasmodium falciparum Isolates from Thailand

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Gaillard, Tiphaine | Sriprawat, Kanlaya | Briolant, Sébastien | Wangsing, Chirapat | Wurtz, Nathalie | Baragatti, Meïli | Lavina, Morgane | Pascual, Aurélie | Nosten, François | Pradines, Bruno

Edité par CCSD ; American Society for Microbiology -

ISI Document Delivery No.: CT6VY Times Cited: 1 Cited Reference Count: 19 Gaillard, Tiphaine Sriprawat, Kanlaya Briolant, Sebastien Wangsing, Chirapat Wurtz, Nathalie Baragatti, Meili Lavina, Morgane Pascual, Aurelie Nosten, Francois Pradines, Bruno Delegation Generale pour l'Armement [10CO405]; Wellcome Trust of Great Britain This study was supported by the Delegation Generale pour l'Armement (grant number 10CO405). The Shoklo Malaria Research Unit is part of the Mahidol Oxford University Research Unit, supported by The Wellcome Trust of Great Britain. 1 0 AMER SOC MICROBIOLOGY WASHINGTON ANTIMICROB AGENTS CH. International audience. Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC(50)s of 13.15 mu M and 31.60 mu M). There was no significant difference between the group with low IC50s versus the group with high IC50s with regard to copy numbers of the Plasmodium falciparum tetQ (pftetQ) gene (P = 0.11) or pfmdt gene (P = 0.87) or the number of PfTetQ KYNNNN repeats (P = 0.72).

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