The new strains Brucella inopinata BO1 and Brucella species 83-210 behave biologically like classic infectious Brucella species and cause death in murine models of infection

Archive ouverte

Jiménez de Bagüés, María P | Iturralde, Maria | Arias, Maykel A | Pardo, Julián | Cloeckaert, Axel | Zygmunt, Michel

Edité par CCSD ; Oxford University Press -

International audience. The novel atypical Brucella strains of this study behave like classic intracellular Brucella pathogens. In addition, they cause death in murine models of infection, as previously published for B. microti, another recently described environmental and wildlife species.

Consulter en ligne

Suggestions

Du même auteur

Different responses of macrophages to smooth and rough Brucella spp.: relationship to virulence.

Archive ouverte | Jiménez de Bagüés, María P | CCSD

By comparing smooth wild-type Brucella strains to their rough mutants, we show that the lipopolysaccharide (LPS) O side chain of pathogenic Brucella has a dramatic impact on macrophage activation. It favors the development of viru...

Regulation of the mitogen-activated protein kinases by Brucella spp. expressing a smooth and rough phenotype: relationship to pathogen invasiveness.

Archive ouverte | Jiménez de Bagüés, María P | CCSD

By comparing smooth wild-type Brucella spp. to their rough mutants, we show that the LPS O chain restricted the activation of the ERK1/2 and p38 mitogen-activated protein kinase (MAPK) pathways, thus preventing the synthesis of im...

The new species Brucella microti replicates in macrophages and causes death in murine models of infection

Archive ouverte | Jiménez de Bagüés, María P | CCSD

International audience. BACKGROUND: The recent isolation of Brucella microti from the common vole, the red fox, and the soil raises the possibility of an eventual reemergence of brucellosis in Europe. In this work, ...

Chargement des enrichissements...