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Dynamics of gene silencing during X inactivation using allele-specific RNA-seq

Archive ouverte | Marks, Hendrik | CCSD

International audience. Background: During early embryonic development, one of the two X chromosomes in mammalian female cells is inactivated to compensate for a potential imbalance in transcript levels with male ce...

Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states

Archive ouverte | Dirks, René a M | CCSD

International audience. BACKGROUND: Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply allele-specific RNA-seq on isogenic B6D2...

Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency

Archive ouverte | Bell, Emma | CCSD

International audience. Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency

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