Causative pathogens of endophthalmitis after intravitreal anti-vegf injection: an international multicenter study

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Busch, Catharina | Iglicki, Matias | Okada, Mali | Gabrielle, Pierre Henry | Cohen, Shai | Mariussi, Miriana | Amphornphruet, Atchara | Cebeci, Zafer | Chaikitmongkol, Voraporn | Couturier, Aude | Fraser-Bell, Samantha | Fung, Adrian t. | Iannetta, Danilo | Radecka, Liga | Laíns, Inês | Rodrigues, Tiago m. | Lupidi, Marco | Ozimek, Małgorzata | Sala-Puigdollers, Anna | Rehak, Matus | Loewenstein, Anat | Zur, Dinah | For The International Retina Group (irg), .

Edité par CCSD ; Karger -

International audience. Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (= 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.

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