Subfoveal choroidal thickness, cardiovascular history, and risk factors in the elderly: the Montrachet study

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Arnould, Louis | Seydou, Alassane | Gabrielle, Pierre Henry | Guenancia, Charles | Tzourio, Christophe | Bourredjem, Abderrahmane | El Alami, Youssef | Daien, Vincent | Binquet, Christine | Bron, Alain M. | Creuzot-Garcher, Catherine

Edité par CCSD ; Association for Research in Vision and Ophthalmology -

International audience. Purpose: To measure subfoveal choroidal thickness (SFCT) in the elderly and to determine the associations among SFCT, cardiovascular history, and the 10-year risk of fatal cardiovascular disease (CVD). Methods: We conducted a population-based study, the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease) study, in subjects older than 75 years. SFCT was measured with spectral-domain optical coherence tomography (SD-OCT) with enhanced-depth mode imaging. Participants underwent a comprehensive eye examination. The history of CVD, CVD risk factors, and a score-based estimation of their 10-year risk of cardiovascular mortality (Heart Score) were collected. Results: Overall, 764 participants were retained for analysis. The mean SFCT was 206.4 +/- 83.0 mum. The mean age was 81.9 +/- 3.6 years. After a multivariable analysis, older age (beta = -32.56 mum, P < 0.001) and longer axial length (beta = -20.71 mum, P < 0.001) were independently associated with thinner SFCT. SFCT was not significantly associated with sex, cardiovascular history, classical CVD risk factors, or prognostic risk score. Conclusions: This study confirms that longer axial length and older age are associated with thinner SFCT. However, SFCT does not appear to be a biomarker for cardiovascular history in this study.

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