Syracuse

90th Anniversary Commentary: The mTORC1 Complex-A central player in the control and regulation of amino acid sfficiency

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Tomé, Daniel, D.

Edité par CCSD ; American Society for Nutrition -

International audience. The ability of cells to respond to nutrient availability and to changes in environmental conditions by appropriate adaptation of anabolic and catabolic processes, cell growth, and proliferation is of fundamental importance for survival. Numerous studies have been conducted during the last few decades to identify signals and cellular mechanisms involved in these means of regulation. The pioneering paper by Anthony et al. (1) published in The Journal of Nutrition in 2000 showed that the BCAA leucine can stimulate protein synthesis in skeletal muscle in vivo in food-deprived rats and that the leucine-dependent signaling pathways involved in this stimulation include the protein kinase mechanistic target of rapamycin (mTOR) pathway.

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