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Cullin-5 mutants reveal collective sensing of the nucleocytoplasmic ratio in Drosophila embryogenesis

Archive ouverte | Hayden, Luke | CCSD

International audience. In most metazoans, early embryonic development is characterized by rapid division cycles that pause before gastrulation at the midblastula transition (MBT).1 These cleavage divisions are acco...

Two-fluid dynamics and micron-thin boundary layers shape cytoplasmic flows in early Drosophila embryos

Archive ouverte | Hernández-López, Claudio | CCSD

International audience. Cytoplasmic flows are widely emerging as key functional players in development. In early Drosophila embryos, flows drive the spreading of nuclei across the embryo. Here, we combine hydrodynam...

Optogenetic inhibition of Delta reveals digital Notch signaling output during tissue differentiation

Archive ouverte | Viswanathan, Ranjith | CCSD

International audience. Spatio-temporal regulation of signalling pathways plays a key role in generating diverse responses during the development of multicellular organisms. The role of signal dynamics in transferri...

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