Identification of new candidate therapeutic target genes in head and neck squamous cell carcinomas

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Sablin, Marie Paule | Dubot, Coraline | Klijanienko, Jerzy T. | Vacher, Sophie | Ouafi, Lamia | Chemlali, Walid | Caly, Martial | Sastre-Garau, Xavier X. | Lappartient, Emmanuelle | Mariani, Odette | Rodriguez, José F. | Jouffroy, Thomas | Girod, Angélique | Calugaru, Valentin | Hoffmann, Caroline | Lidereau, Rosette | Berger, Frédérique | Kamal, Maud | Bieche, Ivan | Le Tourneau, Christophe

Edité par CCSD ; Impact journals -

International audience. Background: We aimed at identifying druggable molecular alterations at the RNA level from untreated HNSCC patients, and assessing their prognostic significance. Methods: We retrieved 96 HNSCC patients who underwent primary surgery. Realtime quantitative RT-PCR was used to analyze a panel of 42 genes coding for major druggable proteins. Univariate and multivariate analyses were performed to assess the prognostic significance of overexpressed genes. Results: Median age was 56 years [35-78]. Most of patients were men (80%) with a history of alcohol (70.4%) and/or tobacco consumption (72.5%). Twelve patients (12%) were HPV-positive. Most significantly overexpressed genes involved cell cycle regulation (CCND1 [27%], CDK6 [21%]), tyrosine kinase receptors (MET [18%], EGFR [14%]), angiogenesis (PGF [301%], VEGFA [14%]), and immune system (PDL1/CD274 [28%]). PIK3CA expression was an independent prognostic marker, associated with shorter disease-free survival. Conclusions: We identified druggable overexpressed genes associated with a poor outcome that might be of interest for personalizing treatment of HNSCC patient

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