Antibacterial, antiproliferative and antioxidant activity of leaf extracts of selected Solanaceae species

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Fadl Almoulah, Nalah | Voynikov, Yulian | Gevrenova, Reneta | Schohn, Hervé | Tzanova, Tzvetomira | Yagi, Sakina | Thomas, Justine | Mignard, Benoît | Ahmed, Abdelazim Abbas | El Siddig, Marmar A. | Spina, Rosella | Laurain-Mattar, Dominique

Edité par CCSD ; Elsevier -

International audience. Plants belonging to the Solanaceae family are generally used in Sudanese traditional medicine for the treatment of different ailments. This study aimed at the evaluation of in vitro antibacterial, antiproliferative and antioxidant activities of methanolic leaf extracts and steroidal glycoalkaloids fractions (SGAFs) of Solanum incanum L., S. schimperianum Hochst, S. nigrum L., Physalis lagascae Roem. & Schult. and Withania somnifera (L) Dunal. Methods: Antibacterial activity of the methanolic extracts and SGAFs was determined against two Gram-positive and two Gram-negative bacteria by microdilution method. Anti-proliferative activity was determined against human cell lines (MCF7 and MDA-MB-231, HT29 and HCT116) by the thiazolyl blue tetrazolium bromide (MTT) procedure. Antioxidant activity was evaluated by diphenyl 2 pycril hydrazil (DPPH) and 2,2′-azino-bis 3-ethylbenzthiazoline-6-sulphonic acid (ABTS) scavenging radical methods. Methanolic extract of S. schimperianum was analyzed using liquid chromatography coupled to an Orbitrap mass spectrometer with an electrospray ionization source (LC–MS).

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