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Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography

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Tusamda Wakhloo, Nayana | Anders, Sebastian | Badique, Florent | Eichhorn, Melanie | Brigaud, Isabelle | Petithory, Tatiana | Vassaux, Maxime | Milan, Jean-Louis | Freund, Jean-Noël | Rühe, Jürgen | Davidson, Patricia | Pieuchot, Laurent | Anselme, Karine

Edité par CCSD ; Elsevier -

International audience. Cell deformation occurs in many critical biological processes, including cell extravasation during immune response and cancer metastasis. These cells deform the nucleus, its largest and stiffest organelle, while passing through narrow constrictions in vivo and the underlying mechanisms still remain elusive. It is unclear which biochemical actors are responsible and whether the nucleus is pushed or pulled (or both) during deformation. Herein we use an easily-tunable poly-L-lactic acid micropillar topography, mimicking in vivo constrictions to determine the

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