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The Rab5 Effector Rabankyrin-5 Regulates and Coordinates Different Endocytic Mechanisms

Archive ouverte | Schnatwinkel, Carsten | CCSD

International audience. The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5...

APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment

Archive ouverte | Miaczynska, Marta | CCSD

International audience. Signals generated in response to extracellular stimuli at the plasma membrane are transmitted through cytoplasmic transduction cascades to the nucleus. We report the identification of a pathw...

Automated de novo sequencing of proteins using the differential scanning technique

Archive ouverte | Uttenweiler-Joseph, Sandrine | CCSD

International audience. Despite the progress in genomic DNA sequencing de novo sequencing of peptides is still required in a biological research environment since many experiments are done in organisms whose genomes...

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