GNAI2 variants predict nonsteroidal anti‐inflammatory drug hypersensitivity in a genome‐wide study

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Blanca, Miguel | Oussalah, Abderrahim | Cornejo‐garcía, José Antonio | Blanca‐lópez, Natalia | Guéant-Rodriguez, Rosa-Maria | Doña, Inmaculada | Mayorga, Cristobalina | Chery, Céline | Rouyer, Pierre | Carmona, Francisco David | Bossini Castillo, Lara | Canto, Gabriela | Martin, Javier | Torres, María José | Guéant, Jean-Louis

Edité par CCSD ; Wiley -

International audience. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in drug hypersensitivity reactions through mechanisms that may involve genetic predisposition. We performed a fine-mapping GWAS in patients with NSAID-induced hypersen-sitivity reactions with cross-intolerance belonging to the group of NSAID-induced urticaria, angioedema, and anaphylaxis (NIUAA) (2) and matched controls from South Spain, and we replicated the re-sults in patients and paired controls from central Spain. GNAI2 was a significant predictor of NSAID-induced hypersensitivity reactions. This association may reflect its influence on the activation of leukot-riene receptors and the recruitment of immune cells involved in the pathological mechanisms of NSAID hypersensitivity.

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