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The KMT2A recombinome of acute leukemias in 2023

Archive ouverte | Meyer, C. | CCSD

International audience. Abstract Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the data ...

Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam KO mouse model

Archive ouverte | Chatel, Benjamin | CCSD

International audience. Mitochondrial diseases are genetic disorders leading to an impaired mitochondrial function and resulting in exercise intolerance and muscle weakness. In patients, muscle fatigue due to defect...

Relationship of cardiac remodeling and perfusion alteration with hepatic lipid metabolism in a prediabetic high fat high sucrose diet female rat model

Archive ouverte | Jouenne, A. | CCSD

International audience. Background and Aims: Cardiovascular disease (CVD) is known to be linked with metabolic associated fatty liver disease and type 2 diabetes, but few studies assessed this relationship in predia...

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