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Orientia tsutsugamushi, the causative agent of scrub typhus, induces an inflammatory program in human macrophages.

Archive ouverte | Tantibhedhyangkul, Wiwit | CCSD

International audience. Scrub typhus is a life-threatening disease caused by Orientia tsutsugamushi, a bacterium that primarily infects endothelial cells both in vitro and in vivo. Evidence suggests that the interac...

MALDI-TOF MS monitoring of PBMC activation status in sepsis

Archive ouverte | Daumas, Aurélie | CCSD

International audience. BACKGROUND:MALDI-TOF mass spectrometry (MS) on whole cells enables the detection of different cell types and cell activation. Here, we wondered whether this approach would be useful to invest...

Imbalance of Circulating Monocyte Subsets and PD-1 Dysregulation in Q Fever Endocarditis: The Role of IL-10 in PD-1 Modulation

Archive ouverte | Ka, Mignane, B | CCSD

International audience. Q fever endocarditis, a severe complication of Q fever, is associated with a defective immune response, the mechanisms of which are poorly understood. We hypothesized that Q fever immune defi...

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