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Involvement of Basal Ganglia Network in Motor Disabilities Induced by Typical Antipsychotics

Archive ouverte | Chetrit, Jonathan | CCSD

International audience. Clinical treatments with typical antipsychotic drugs (APDs) are accompanied by extrapyramidal motor side-effects (EPS) such as hypokinesia and catalepsy. As little is known about electrophysi...

Inhibiting subthalamic D5 receptor constitutive activity alleviates abnormal electrical activity and reverses motor impairment in a rat model of Parkinson's disease.

Archive ouverte | Chetrit, Jonathan | CCSD

International audience. Burst firing has been reported as a pathological activity of subthalamic nucleus (STN) neurons in Parkinson's disease. However, the origin of bursts and their causal link with motor deficits ...

D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism

Archive ouverte | Ballion, Bérangère | CCSD

International audience. In Parkinson's disease dopamine depletion imbalances the two major output pathways of the striatum. L-DOPA replacement therapy is believed to correct this imbalance by providing effective D1 ...

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