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Involvement of Basal Ganglia Network in Motor Disabilities Induced by Typical Antipsychotics

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Chetrit, Jonathan | Ballion, Bérangère | Laquitaine, Steeve | Belujon, Pauline | Morin, Stéphanie | Taupignon, Anne | Bioulac, Bernard | Gross, Christian, E | Benazzouz, Abdelhamid

Edité par CCSD ; Public Library of Science -

International audience. Clinical treatments with typical antipsychotic drugs (APDs) are accompanied by extrapyramidal motor side-effects (EPS) such as hypokinesia and catalepsy. As little is known about electrophysiological substrates of such motor disturbances, we investigated the effects of a typical APD, alpha-flupentixol, on the motor behavior and the neuronal activity of the whole basal ganglia nuclei in the rat.

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