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Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

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Helmy, R. | Denhaerynck, K. | Berben, L. | Dobbels, F. | Russell, C. L. | Roza, B. D. | de Geest, S. | Crespo-Leiro, M. G. | Guppies, S. | de Simone, P. | Groenewoud, A. | Kugler, C. | Ohler, L. | van Cleemput, J. | Poncelet, A. J. | Sebbag, L. | Michel, M. | Bernard, A. | Doesch, A. | Livi, U. | Potena, L. | Brossa-Loidi, V. | Segovia-Cubero, J. | Almenar-Bonet, L. | Saint-Gerons, C. S. | Mohacsi, P. | Horvath, E. | Riotto, C. | Parry, G. | Firouzi, A. | Kozuszko, S. | Haddad, H. | Kaan, A. | Fisher, G. | Miller, T. | Flattery, M. | Ludrosky, K. | Albert, N. | Coleman, B. | Trammell, J. | Epstein, F. | St Clair, K. | Kao, A. | Molina, M. | Canales, K. R. | Almeida, S. S., De | Ayoub, A. C. | Barone, F. | Harkess, M. | Maddicks-Law, J. | Team, Bright Study

Edité par CCSD -

International audience. Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. Findings: MNA was significantly (alpha = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20). (C) 2018 Elsevier Inc. All rights reserved.

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