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Reduced naïve CD8+T-cell priming efficacy in elderly adults

Archive ouverte | Briceño, Olivia | CCSD

International audience. Aging is associated with impaired vaccine efficacy and increased susceptibility to infectious and malignant diseases. CD8 + T-cells are key players in the immune response against pathogens an...

Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old

Archive ouverte | Nicoli, Francesco | CCSD

International audience. Background: Advanced age is accompanied by a decline of immune functions, which may play a role in increased vulnerability to emerging pathogens and low efficacy of primary vaccinations in el...

Priming of Qualitatively Superior Human Effector CD8+ T Cells Using TLR8 Ligand Combined with FLT3 Ligand

Archive ouverte | Lissina, Anna | CCSD

International audience. The quality of Ag-specific CD8+ T cell responses is central to immune efficacy in infectious and malignant settings. Inducing effector CD8+ T cells with potent functional properties is theref...

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