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Single-filament kinetic studies provide novel insights into regulation of actin-based motility.

Archive ouverte | Shekhar, Shashank | CCSD

International audience. Polarized assembly of actin filaments forms the basis of actin-based motility and is regulated both spatially and temporally. Cells use a variety of mechanisms by which intrinsically slower p...

Enhanced Depolymerization of Actin Filaments by ADF/Cofilin and Monomer Funneling by Capping Protein Cooperate to Accelerate Barbed-End Growth

Archive ouverte | Shekhar, Shashank | CCSD

International audience. A living cell's ability to assemble actin filaments in intracellular motile processes is directly dependent on the availability of polymerizable actin monomers, which feed polarized filament ...

Global treadmilling coordinates actin turnover and controls the size of actin networks

Archive ouverte | Carlier, Marie-France | CCSD

International audience. Various cellular processes (including cell motility) are driven by the regulated, polarized assembly of actin filaments into distinct force-producing arrays of defined size and architecture. ...

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