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Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation.

Archive ouverte | Nasr, Rihab | CCSD

International audience. Retinoic acid and arsenic trioxide target the protein stability and transcriptional repression activity of the fusion oncoprotein PML-RARA, resulting in regression of acute promyelocytic leuk...

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

Archive ouverte | Nasr, Rihab | CCSD

International audience

Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins.

Archive ouverte | Sahin, Umut | CCSD

International audience. The promyelocytic leukemia (PML) protein organizes PML nuclear bodies (NBs), which are stress-responsive domains where many partner proteins accumulate. Here, we clarify the basis for NB form...

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