Afficher la couverture 'Data on atherosclerosis specific antibody conjugation to nanoemulsions | Prévot, Geoffrey' en grand format
/5

0 avis

Data on atherosclerosis specific antibody conjugation to nanoemulsions

Archive ouverte

Prévot, Geoffrey | Duonor-Cerutti, Martine | Larivière, Mélusine | Laroche-Traineau, Jeanny | Jacobin-Valat, Marie Josée | Barthelemy, Philippe | Clofent-Sanchez, Gisèle | Crauste-Manciet, Sylvie

Edité par CCSD ; Elsevier -

International audience. This article present data related to the publication entitled "Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging" (Prévot et al., 2017) [1]. Herein we describe the engineering in the baculovirus-insect cell system and purification processes of the human scFv-Fc TEG4-2C antibody, specific of platelets within the atheroma plaque. For molecular targeting purpose, atheroma specific antibody was conjugated to nanoemulsions (NEs) using a heterobifunctional linker (DSPE-PEG-maleimide). Atheroma labelling was assayed by immunochemistry on arterial sections from rabbits.

Suggestions

Du même auteur

A Recombinant Human Anti-Platelet scFv Antibody Produced in Pichia pastoris for Atheroma Targeting

Archive ouverte | Vallet-Courbin, Amélie | CCSD

International audience. Cells of the innate and adaptive immune system are key factors in the progression of athero-sclerotic plaque, leading to plaque instability and rupture, potentially resulting in acute ather-o...

Development of anti-chloro 192 tyrosine HDL apoA-I antibodies for the immunodiagnosis of cardiovascular diseases

Archive ouverte | Gisèle, Clofent-Sanchez | CCSD

International audience. High density lipoproteins (HDL) are considered cardio protective. Apolipoprotein A-I (apoA-I), a major component of HDL helps in reverse cholesterol transport, whose function is greatly affec...

Recent Advances in the Molecular Imaging of Atherosclerosis

Archive ouverte | Larivière, Mélusine | CCSD

International audience

Chargement des enrichissements...