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The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation

Archive ouverte | Arbona, Jean-Michel | CCSD

International audience. The time-dependent rate I(t) of origin firing per length of unreplicated DNA presents a universal bell shape in eukaryotes that has been interpreted as the result of a complex time-evolving i...

FORK-seq: single molecule profiling of DNA replication

Archive ouverte | Hennion, Magali | CCSD

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Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths

Archive ouverte | Arbona, Jean-Michel | CCSD

International audience. In human and other metazoans, the determinants of replication origin location and strength are still elusive. Origins are licensed in G1 phase and fired in S phase of the cell cycle, respecti...

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