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MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells

Archive ouverte | Richards, Paul | CCSD

International audience. Although the mechanisms by which glucose regulates insulin secretion from pancreatic β-cells are now well described, the way glucose modulates gene expression in such cells needs more underst...

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

Archive ouverte | Gonzalez-Duque, Sergio | CCSD

International audience. Although CD8+ T-cell-mediated autoimmune β cell destruction occurs in type 1 diabetes (T1D), the target epitopes processed and presented by β cells are unknown. To identify them, we combined ...

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

Archive ouverte | Solimena, Michele | CCSD

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