The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration

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Sachdev, Perminder | Lipnicki, Darren | Kochan, Nicole | Crawford, John, D. | Thalamuthu, Anbupalam | Andrews, Gavin | Brayne, Carol | Matthews, Fiona | Stephan, Blossom | Lipton, Richard | Katz, Mindy | Ritchie, Karen, A. | Carrière, Isabelle | Ancelin, Marie-Laure | Lam, Linda | Wong, Candy | Fung, Ada | Guaita, Antonio | Vaccaro, Roberta | Davin, Annalisa | Ganguli, Mary | Dodge, Hiroko | Hughes, Tiffany | Anstey, Kaarin | Cherbuin, Nicolas | Butterworth, Peter | Ng, Tze Pin | Gao, Qi | Reppermund, Simone | Brodaty, Henry | Schupf, Nicole | Manly, Jennifer | Stern, Yaakov | Lobo, Antonio | Lopez-Anton, Raúl | Santabárbara, Javier

Edité par CCSD ; Public Library of Science -

International audience. BACKGROUND : Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).METHODS : Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.RESULTS : The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).CONCLUSION : Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

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