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Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways

Archive ouverte | Talhaoui, Ibtissam | CCSD

International audience. Background: Base excision repair (BER) is the major pathway for repair of single oxidized nucleobases. Results: Bifunctional DNA glycosylases and AP endonucleases are able to remove cross-lin...

Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli

Archive ouverte | Zutterling, Caroline | CCSD

International audience. Background: DNA repair is essential to counteract damage to DNA induced by endo-and exogenous factors, to maintain genome stability. However, challenges to the faithful discrimination between...

Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori

Archive ouverte | Turgimbayeva, Aigerim | CCSD

International audience. Apurinic/apyrimidinic (AP) endonucleases play critical roles in the repair of abasic sites and strand breaks in DNA. Complete genome sequences of Helicobacter pylori reveal that this bacteria...

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