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Post-pulse addition of trans-cyclohexane-1,2-diol improves electrotransfer mediated gene expression in mammalian cells

Archive ouverte | Pasquet, L. | CCSD

International audience. Electric field mediated gene transfer is facing a problem in expression yield due to the poor transfer across the nuclear envelope. Trans-cyclohexane-1,2-diol (TCHD) was shown to significantl...

Electrotransfer of CpG free plasmids enhances gene expression in skin

Archive ouverte | Chabot, S. | CCSD

International audience. Skin is a very suitable target for gene therapy and DNA vaccination due to its accessibility, its surface, its ability to produce transgenes. Gene electrotransfer (GET) to the skin is under d...

Electrochemotherapy guided by intraoperative fluorescence imaging for the treatment of inoperable peritoneal micro-metastases

Archive ouverte | Josserand, V. | CCSD

International audience. Surgery is often the first therapeutic indication in cancer. Patient survival essentially depends on the completeness of tumor resection. This is a major challenge, particularly in patients w...

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