Afficher la couverture 'The healthy ageing gene expression signature for Alzheimer’s disease diagnosis: a random sampling perspective | Jacob, Laurent' en grand format
/5

0 avis

The healthy ageing gene expression signature for Alzheimer’s disease diagnosis: a random sampling perspective

Archive ouverte

Jacob, Laurent | Speed, Terence, Paul

Edité par CCSD ; BioMed Central -

International audience. In a recent publication, Sood et al. (Genome Biol 16:185, 2015) presented a set of 150 probe sets that could be used in the diagnosis of Alzheimer's disease (AD) based on gene expression. We reproduce some of their experiments and show that their signature is indeed able to discriminate between AD and control patients using blood gene expression in two cohorts. We also show that its performance does not stand out compared to randomly sampled sets of 150 probe sets from the same array.

Suggestions

Du même auteur

Statistical analysis of Single Nucleotide Polymorphism microarrays in cancer studies

Archive ouverte | Neuvial, Pierre | CCSD

35 pages. International audience. In this chapter, we focus on statistical questions raised by the identification of copy number alterations in tumor samples using genotyping microarrays, also known as Single Nucleo...

A molecular threshold for effector CD8+ T cell differentiation controlled by transcription factors Blimp-1 and T-bet

Archive ouverte | Xin, Annie | CCSD

International audience

Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network

Archive ouverte | Haupt, Sue | CCSD

International audience. The disproportionately high prevalence of male cancer is poorly understood. We tested for sex-disparity in the functional integrity of the major tumor suppressor p53 in sporadic cancers. Our ...

Chargement des enrichissements...